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KMID : 1023120110090040295
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Korean Journal of Aesthetic Society
2011 Volume.9 No. 4 p.295 ~ p.304
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Hair growth effect of ethyl acetate and water fractions of Sparassis crispa extracts on hair-removed C57BL/6 mice
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Ryu Eun-Mi
Shin Hyun-Jae
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Abstract
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Sparassis crispa is an edible and medicinal mushroom, which commonly called ‘cauliflower mushroom’. S. crispa is known to be good sources of food and nutraceuticals due to their rich flavors and β-glucan contents as well as antiviral and anticancer compounds. C57BL/6 mice, the widely used lab mouse strain, were used in this animal study because of their availability and a similar hair growth cycle to human hair. Herein, hair-removed five-year-old C57BL/6 mice were used to examine the effect of S. crispa extracts for 70% ethanol extract, ethyl acetate extract, and water extract on hair growth stimulation. The extracts and control compounds were topically treated once a day for 4 weeks. The hair growth was photographically and histologically examined during the total period of 4 weeks. Overall, hair growth of S. crispa water extracts test group was stimulated compared to ethyl acetate extract and 70% extract, along with positive control (3% minoxidil) and negative control (normal). The whole study showed a significant improvement of hair growth effect of S. crispa extracts. This findings suggests that S. crispa extract has a hair growth promoting activity, but more works should be planned to elucidate the hair growth mechanism.
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KEYWORD
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Sparassis crispa extracts, Alopecia, scalp, Hair growth, C57BL/6 mouse
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